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High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
Published on: July 6, 2012
Solid-phase synthesis of oligosaccharide drugs: a review
Meenakshi Dhanawat1, Sushant Kumar Shrivastava
1Department of Pharmaceutics, Institute of Technology, Banaras Hindu University Varanasi, -22100, India. meenakshi.itbhu@gmail.com
Mini Reviews in Medicinal Chemistry
|February 10, 2009
Summary
Solid-phase synthesis offers a fast and accurate method for creating complex carbohydrates. This review explores solid-phase techniques for synthesizing biologically active oligosaccharides and their applications.
Area of Science:
- Carbohydrate Chemistry
- Organic Synthesis
Background:
- Solid-phase synthesis involves attaching a reactant to a polymeric support via a linker.
- This method is increasingly favored for carbohydrate transformations.
Purpose of the Study:
- To review various solid-phase oligosaccharide synthesis methods.
- To highlight the applications of these synthetic strategies.
Main Methods:
- Solid-phase synthesis utilizing polymeric supports and linkers.
- Focus on techniques applicable to oligosaccharide construction.
Main Results:
- Solid-phase synthesis provides a rapid and precise route to complex carbohydrates.
- Enables the efficient production of biologically relevant oligosaccharides.
Conclusions:
- Solid-phase synthesis is a powerful tool for oligosaccharide preparation.
- Its application is crucial for advancing carbohydrate-based research and development.
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