Related Experiment Video
Updated: Jun 25, 2026
Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs
Published on: July 23, 2016
Intravitreal toxicity of ketorolac tris salt and flurbiprofen
Ana Munoz Morales1, Muhamet Kivilcim, Gholam A Peyman
1Department of Ophthalmology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA.
Background And Objective:
To determine the retinal toxicity of intravitreal ketorolac tris salt and flurbiprofen.
Materials And Methods:
Thirty-two New Zealand rabbits were injected intravitreally with 125, 250, or 500 microg or 1 mg of ketorolac tris salt or flurbiprofen in one eye and 8 fellow eyes were injected with 5% dextrose as a control. All animals underwent indirect ophthalmoscopy and slit-lamp biomicroscopy before injection and on days 1, 7, and 14 after the intravitreal injection. Electroretinography was performed on all animals before injection and on day 14 after the injection before the animals were killed. The enucleated eyes were prepared for histology.
Results:
Clinical examination, electroretinography results, and histological evaluation demonstrated no signs of retinal toxicity for either drug at any dose.
Conclusions:
Intravitreal doses up to 1 mg of ketorolac tris salt and 1 mg of flurbiprofen did not cause retinal toxicity in the rabbit eye.
