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Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
Published on: March 17, 2016
Energy restriction for breast cancer prevention
Anthony Howell1, Mary Chapman, Michelle Harvie
1Christie Hospital NHS Trust, University of Manchester, CRUK Department of Medical Oncology, UK. maria.parker@christie-tr.nwest.nhs.uk
Abstract:
Weight gain in adult life is an important risk factor for breast cancer. Observational studies indicate that pre- or postmeno-pausal weight loss is associated with a reduction in risk of postmenopausal breast cancer. Here we summarise lifestyle changes including continuous or intermittent energy restriction and/or exercise which may be beneficial for preventing breast cancer and also potential pharmacological approaches to prevention using energy restriction mimetic agents (ERMAs).
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