Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rabies01:28

Rabies

Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...
Rab Proteins01:14

Rab Proteins

Rab proteins constitute the largest family of monomeric GTPases, of which 70 members are present in humans. Rab proteins and their effectors regulate consecutive stages of vesicle transport such as vesicle transport, docking, and fusion to the correct recipient membrane.
Rab proteins switch between a cytosolic, GDP-bound inactive state and a membrane-anchored, GTP-bound active state. By themselves, Rabs show slow rates of GDP/GTP exchange and GTP hydrolysis. Thus, Rab proteins are considered...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rab Cascades01:25

Rab Cascades

Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
Size and Structure of Viral Genomes01:26

Size and Structure of Viral Genomes

Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Fukushima et al. Long-Term Immunogenicity of Rabies Pre-Exposure Prophylaxis in Japanese Adult Travelers: Comparison of Dosing Regimens. <i>Vaccines</i> 2025, <i>13</i>, 1169.

Vaccines·2026
Same author

Persistence and booster response of rabies antibodies among health care workers with multiple vaccinations.

Tropical medicine and health·2026
Same author

Risk factors for delayed post-exposure prophylaxis among Japanese travelers with animal bite exposure: A multicenter retrospective study.

Travel medicine and infectious disease·2026
Same author

Serological and molecular assessment of severe fever with thrombocytopenia syndrome virus infection in wild boars from two adjacent endemic prefectures in Japan.

The Journal of veterinary medical science·2026
Same author

Monitoring the immune landscape against rabies in domestic dogs, Japan.

Comparative immunology, microbiology and infectious diseases·2026
Same author

Ambient PM<sub>2</sub>.<sub>5</sub> exposure and increased dengue case fatality: a global multi-country analysis.

Environmental pollution (Barking, Essex : 1987)·2026
Same journal

[Neuropathological Autopsies in Japan: Current Scenario and Challenges].

Brain and nerve = Shinkei kenkyu no shinpo·2026
Same journal

[Telemedicine and Digital Technologies in Neurological Intractable Diseases].

Brain and nerve = Shinkei kenkyu no shinpo·2026
Same journal

[Disaster Countermeasures for Intractable Neurological Disease].

Brain and nerve = Shinkei kenkyu no shinpo·2026
Same journal

[Supporting Health Care Transition for Patients with Childhood-Onset Chronic Conditions: Within Intractable Disease Care in Japan].

Brain and nerve = Shinkei kenkyu no shinpo·2026
Same journal

[Multidisciplinary Collaboration between Hospitals and Clinics at the University Hospital and the Core Hospital for the Treatment of Intractable Diseases].

Brain and nerve = Shinkei kenkyu no shinpo·2026
Same journal

[The Role of Coordinators for Intractable Diseases in Japan].

Brain and nerve = Shinkei kenkyu no shinpo·2026
See all related articles

Related Experiment Video

Updated: Jun 25, 2026

A Trap-Vaccinate-Release Protocol for Immunization of Skunks and Additional Rabies Vectors Against Rabies
04:10

A Trap-Vaccinate-Release Protocol for Immunization of Skunks and Additional Rabies Vectors Against Rabies

Published on: November 29, 2024

[Rabies].

Akira Nishizono1

  • 1Department of Microbiology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita 879-5593, Japan.

Brain and Nerve = Shinkei Kenkyu No Shinpo
|February 25, 2009
PubMed
Summary
This summary is machine-generated.

Rabies is a deadly viral encephalitis transmitted by animal saliva. Post-exposure treatment is crucial for prevention as no cure exists once symptoms appear.

More Related Videos

Analysis of Iophenoxic Acid Analogues in Small Indian Mongoose (Herpestes Auropunctatus) Sera for Use as an Oral Rabies Vaccination Biological Marker
11:28

Analysis of Iophenoxic Acid Analogues in Small Indian Mongoose (Herpestes Auropunctatus) Sera for Use as an Oral Rabies Vaccination Biological Marker

Published on: May 31, 2019

Whole Genome Sequencing for Rapid Characterization of Rabies Virus Using Nanopore Technology
10:26

Whole Genome Sequencing for Rapid Characterization of Rabies Virus Using Nanopore Technology

Published on: August 18, 2023

Related Experiment Videos

Last Updated: Jun 25, 2026

A Trap-Vaccinate-Release Protocol for Immunization of Skunks and Additional Rabies Vectors Against Rabies
04:10

A Trap-Vaccinate-Release Protocol for Immunization of Skunks and Additional Rabies Vectors Against Rabies

Published on: November 29, 2024

Analysis of Iophenoxic Acid Analogues in Small Indian Mongoose (Herpestes Auropunctatus) Sera for Use as an Oral Rabies Vaccination Biological Marker
11:28

Analysis of Iophenoxic Acid Analogues in Small Indian Mongoose (Herpestes Auropunctatus) Sera for Use as an Oral Rabies Vaccination Biological Marker

Published on: May 31, 2019

Whole Genome Sequencing for Rapid Characterization of Rabies Virus Using Nanopore Technology
10:26

Whole Genome Sequencing for Rapid Characterization of Rabies Virus Using Nanopore Technology

Published on: August 18, 2023

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Context:

  • Rabies is a fatal viral encephalitis transmitted via infected animal saliva.
  • It remains a significant global public health concern, particularly in developing nations with endemic dog rabies.
  • Re-emerging rabies cases and Lyssavirus infections are noted in developed countries and via bat transmission in Europe and the US.

Purpose:

  • To highlight the global impact and transmission dynamics of rabies.
  • To emphasize the critical role of post-exposure treatment (PET) in rabies prevention.
  • To underscore the need for continued vigilance despite successful control measures in some regions.

Summary:

  • Rabies virus causes fatal encephalitis, primarily spread through infected animal saliva, posing a major public health challenge globally.
  • While furious rabies presents distinct symptoms, paralytic rabies can be misdiagnosed, making prompt post-exposure prophylaxis (PEP) essential.
  • PEP, including rabies immunoglobulin (RIG) for severe exposures, is the sole effective method to prevent rabies after potential infection.

Impact:

  • Rabies prevention relies heavily on timely post-exposure treatment, as no cure exists once clinical symptoms manifest.
  • Understanding rabies pathogenesis through tools like reverse genetics is vital for developing improved control strategies.
  • Maintaining rabies-free status requires ongoing animal surveillance and vaccination programs, as demonstrated by Japan's long-term success.