Hysteroscopic polypectomy without cycle cancellation in IVF cycles.

Area of Science:

• Reproductive Medicine
• Gynecologic Surgery

Background:

• Endometrial polyps can negatively impact endometrial texture and contribute to implantation failure.
• Current management strategies for endometrial polyps in in vitro fertilization (IVF) cycles lack consensus.

Purpose of the Study:

• To evaluate the safety and efficacy of hysteroscopic polypectomy in patients undergoing assisted reproduction treatment (ART).
• To assess the impact of polyp resection on pregnancy outcomes in ART cycles.

Main Methods:

• Nine patients with endometrial polyps (<1.5 cm) diagnosed via transvaginal ultrasonography underwent hysteroscopic polypectomy.
• Polypectomy was performed during ovarian stimulation (standard cycles) or hormone replacement therapy (egg donation cycle).
• Embryo transfer occurred 2-16 days post-polypectomy.

Main Results:

• Four out of nine patients achieved pregnancy (two twin, two singleton), with all successful pregnancies ongoing.
• Four patients had unsuccessful outcomes, and one experienced a blighted ovum.
• The interval between polyp resection and embryo transfer ranged from 2 to 16 days.

Conclusions:

• Hysteroscopic polypectomy before embryo transfer in IVF cycles appears to be a viable option, potentially avoiding cycle cancellation.
• Further research with larger patient cohorts is necessary to confirm these preliminary findings and establish definitive management guidelines.