Related Experiment Video
Updated: Jun 24, 2026

07:22
A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
Published on: March 14, 2025
Anaphylactic reaction to bacitracin ointment
Hyland Cronin1, Christen Mowad
1Geisinger Health System, 100 N Academy Ave, MC 14-06, Danville, PA 17822, USA.
Cutis
|April 15, 2009
Summary
A child experienced a severe allergic reaction, including hives and vomiting, after applying bacitracin ointment to a scraped elbow. Prompt epinephrine treatment resolved the anaphylaxis, highlighting a rare but serious risk of this common topical antibiotic.
Area of Science:
- Allergy and Immunology
- Dermatology
- Pediatrics
Background:
- Bacitracin ointment is a commonly used topical antibiotic for minor skin injuries.
- Anaphylaxis is a severe, potentially life-threatening allergic reaction.
Observation:
- An 11-year-old boy developed anaphylactic symptoms including pruritus, diaphoresis, nausea, vomiting, pallor, and hives minutes after bacitracin ointment application.
- Symptoms rapidly progressed from the feet to the head.
Findings:
- The patient experienced a significant anaphylactic reaction attributed to bacitracin ointment.
- Immediate administration of epinephrine led to rapid symptom improvement.
Implications:
- This case underscores the potential for rare, severe allergic reactions to topical bacitracin.
- Healthcare providers should maintain awareness of bacitracin-induced anaphylaxis in pediatric patients.
- Prompt recognition and management of anaphylaxis are crucial for favorable outcomes.
Related Concept Videos
Allergic Reactions: Anaphylaxis
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions
Overview
Inhalation Anthrax
Anthrax is a zoonotic disease caused by Bacillus anthracis, a Gram-positive, spore-forming bacterium. It primarily affects herbivorous animals but can be transmitted to humans through skin contact, ingestion, or inhalation of spores.Cutaneous anthrax, the most common form, typically results from direct contact with bacterial spores through skin abrasions and is generally less severe. Gastrointestinal anthrax results from eating undercooked or contaminated meat. It affects the mouth, throat, or...
Allergic Drug Reactions
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Drug Toxicity: Allergic Reactions
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hypersensitivity Reactions: Immune-Complex Reactions
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...