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Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Related Experiment Video

Updated: Jun 23, 2026

Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples
13:21

Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples

Published on: May 4, 2012

Microarrays in glycoproteomics research.

Tingting Yue1, Brian B Haab

  • 1Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, MI 49503, USA.

Clinics in Laboratory Medicine
|April 25, 2009
PubMed
Summary

Microarrays enable efficient study of molecular interactions in glycobiology. This review covers glycan, lectin, and antibody arrays for understanding carbohydrate-protein binding and glycan structures.

Area of Science:

  • Glycobiology
  • Molecular Biology
  • Biochemistry

Background:

  • Microarrays are powerful tools for analyzing molecular binding interactions.
  • They offer high-throughput analysis with minimal sample and reagent use.
  • Their application is expanding significantly in glycobiology research.

Purpose of the Study:

  • To review the technology and applications of microarrays in glycobiology.
  • To highlight the use of glycan, lectin, and antibody arrays.
  • To explain how these arrays provide complementary data on glycan-protein interactions.

Main Methods:

  • Utilizing glycan arrays to investigate carbohydrate recognition.
  • Employing lectin arrays to assess carbohydrate expression on proteins and cells.

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Microarray Polymer Profiling (MAPP) for High-Throughput Glycan Analysis
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Microarray Polymer Profiling (MAPP) for High-Throughput Glycan Analysis

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Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments
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  • Using antibody arrays to analyze glycan structure variations on proteins.

    • Main Results:

    • Microarrays facilitate the examination of numerous binding interactions simultaneously.
    • Different microarray types (glycan, lectin, antibody) offer distinct insights.
    • These technologies enable comprehensive analysis of glycobiology aspects.

    Conclusions:

    • Microarrays are essential for advancing glycobiology research.
    • Glycan, lectin, and antibody arrays provide complementary data for studying carbohydrate-protein interactions.
    • These platforms are key to understanding complex glycan structures and functions.