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Related Concept Videos

Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
Ovarian Cycle01:27

Ovarian Cycle

The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle length...
In Vitro Fertilization01:24

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
Nondisjunction01:29

Nondisjunction

During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
Fetal Circulation01:14

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...

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Related Experiment Video

Updated: Jun 23, 2026

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators
09:51

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators

Published on: March 21, 2018

[Delivery of twins].

L Sentilhes1, A-C Bouhours, F Biquard

  • 1Service de gynécologie-obstétrique, centre hospitalier universitaire d'Angers, 49033 Angers cedex 01, France. loicsentilhes@hotmail.com

Gynecologie, Obstetrique & Fertilite
|April 28, 2009
PubMed
Summary

Optimal twin delivery management involves active techniques for the second non-vertex twin, reducing risks associated with planned vaginal or combined births. This approach requires specialized obstetric training for improved neonatal outcomes.

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Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas
09:04

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas

Published on: September 5, 2011

Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye
09:52

Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye

Published on: September 5, 2011

Related Experiment Videos

Last Updated: Jun 23, 2026

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators
09:51

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators

Published on: March 21, 2018

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas
09:04

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas

Published on: September 5, 2011

Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye
09:52

Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye

Published on: September 5, 2011

Area of Science:

  • Maternal-Fetal Medicine
  • Obstetrics
  • Neonatal Outcomes

Context:

  • Twin gestations present complex delivery challenges due to high complication rates.
  • Existing Anglo-Saxon studies have limited external validity due to differing management protocols for the second twin, particularly non-vertex presentations.
  • Variations in delivery management, including external cephalic version versus internal version/breech extraction, impact neonatal outcomes.

Purpose:

  • To evaluate optimal delivery strategies for twin gestations, focusing on reducing neonatal morbidity.
  • To propose an active management approach for second non-vertex twin deliveries.
  • To address the limitations of current Anglo-Saxon studies in diverse clinical settings.

Summary:

  • Anglo-Saxon studies indicate increased neonatal morbidity for the second twin in planned vaginal deliveries, especially combined vaginal-cesarean births.
  • The proposed active management for second non-vertex twins aims to decrease the twin-to-twin delivery interval and minimize combined births.
  • This strategy advocates against routine external cephalic version and supports internal version and/or breech extraction, with no evidence for planned cesarean sections in twins under active management.

Impact:

  • Active management requires specialized training in obstetric maneuvers like internal version, emphasizing the need for continued education for junior obstetricians.
  • The role of trial of labor after cesarean delivery in twin gestations is limited within an active management policy.
  • Implementing standardized active management protocols can potentially improve neonatal outcomes and reduce complications in twin deliveries.