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Updated: Jun 23, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Comparative study of retinal nerve fiber layer thickness in normal eyes, ocular hypertensives, preperimetric glaucoma
Vicente Polo1, Jose M Larrosa, Antonio Ferreras
1Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain. vicpolo@telefonica.net
Abstract:
We assessed and compared the retinal nerve fiber layer (RNFL) thickness in normal eyes, ocular hypertensives, preperimetric glaucoma and glaucomatous subjects by means of optical coherence tomography in 449 eye. RNFL in glaucoma patients was significantly thinner than in normal subjects in every location evaluated. Use of optical coherence tomography detects glaucomatous RNFL losses in preperimetric glaucoma and can improve our ability to detect structural damage in clinical practice.
