Related Experiment Video
Updated: Jun 23, 2026
11:32
Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
[Sequelae and death following pneumococcal meningitis]
Jakob Korsholm1, Rasmus Nygård Kristensen, Anders Heslop
1Arhus Universitet Øre-naese-hals-Afdelingenshospital, Arhus Sygehus. jakobkorsholm@gmail.com
Ugeskrift for Laeger
|May 8, 2009
Summary
Early antibiotics for acute otitis media (AOM) may reduce the risk of death and permanent sequelae in otogenic pneumococcal meningitis (OPM). Affected consciousness is a key prognostic factor, with adults facing higher mortality risks.
Area of Science:
- Otolaryngology
- Infectious Diseases
- Neurology
Context:
- Otogenic pneumococcal meningitis (OPM) is a serious complication of acute otitis media (AOM).
- Understanding prognostic factors and outcomes is crucial for effective management.
- Previous studies have highlighted the need for better treatment strategies.
Purpose:
- To evaluate prognostic factors and outcome parameters in patients with OPM.
- To assess the impact of pre-admission antibiotics on OPM outcomes.
- To identify risk factors and guide treatment recommendations for OPM.
Summary:
- A retrospective analysis of 70 OPM patients (1994-2003) revealed an 11% mortality rate and 40% permanent sequelae, including hearing loss.
- Pre-admission antibiotics were linked to reduced mortality and sequelae.
- Affected consciousness was a significant prognostic factor, and adult mortality was four times higher than in children.
Impact:
- Early antimicrobial treatment for AOM, particularly in adults, is recommended to mitigate OPM risks and poor outcomes.
- Audiological evaluation post-hospitalization is essential for OPM survivors.
- Findings inform clinical practice regarding AOM and OPM management.
More Related Videos
Related Concept Videos
01:22Bacterial Meningitis I: Introduction
Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
01:26Bacterial Meningitis II: Pathophysiology
Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
01:30Pneumonia III: Complications and Assessment
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
01:29Pneumonia II: Pathophysiology
The pathophysiology of pneumonia involves the following steps:
01:24Bacterial Meningitis
Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
01:30Pneumonia I: Introduction
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...