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Updated: Jun 23, 2026

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
Published on: July 31, 2016
[Perioperative fluid therapy in perforated ulcers].
Catherine Collin Bjerre1, Kathrine Holte
1Hvidovre Hospital, Gastroenheden, Kirurgisk Sektion. catcollin@yahoo.com
Fluid management for perforated ulcer surgery is suboptimal, with inconsistent data collection and varied administration. Goal-directed fluid therapy is recommended to improve outcomes in high-risk emergency surgery patients.
Area of Science:
- Emergency surgery
- Surgical critical care
- Fluid resuscitation
Context:
- Perforated ulcer surgery is a common emergency procedure with high mortality.
- Perioperative fluid management strategies require further investigation.
- Current practices lack standardized data collection for rational fluid therapy.
Purpose:
- To describe perioperative fluid management in patients undergoing surgery for perforated ulcers.
- To identify potential areas for improvement in fluid management protocols.
- To establish a foundation for future research on fluid therapy in this patient cohort.
Summary:
- A retrospective survey of 45 patients revealed inconsistent fluid balance monitoring, with data availability decreasing significantly postoperatively.
- Perioperative fluid administration showed extensive variation, with minimal preoperative fluid given to most patients.
- No patients were weighed for fluid status assessment, indicating a lack of comprehensive monitoring.
Impact:
- Preoperative fluid management and postoperative monitoring are suboptimal and require optimization.
- Individualized, goal-directed fluid administration is recommended for high-risk emergency surgery patients.
- Improved fluid management may enhance oxygen delivery and patient outcomes in critical surgical scenarios.
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