Related Experiment Video
Updated: Jun 23, 2026
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Scopolamine-induced migraine like headache.
Ken Ikeda1, Yuji Kawase, Takanori Takazawa
1Department of Neurology, Toho University Omori Medical Center, Tokyo. keni@med.toho-u.ac.jp
Internal Medicine (Tokyo, Japan)
|May 8, 2009
Summary
Scopolamine butylbromide (SB) can trigger severe headaches resembling migraine without aura in individuals with a history of migraine. Caution is advised when using SB, as it may worsen existing migraines.
Area of Science:
- Neurology
- Pharmacology
Background:
- Scopolamine butylbromide (SB) is frequently used in Japan for gastric X-ray examinations.
- This study investigates the clinical characteristics of headaches induced by SB.
Observation:
- SB-induced headaches occurred within 20 minutes of intramuscular SB administration (20 mg/body).
- All 54 subjects experiencing SB-induced headache had a history of migraine.
- Headache characteristics included pulsating pain, nausea, vomiting, and severe intensity requiring bed rest, similar to migraine without aura.
Findings:
- SB-induced headaches were diagnosed as acute substance use headaches (ICHD-II code 8.1).
- Headaches typically lasted 6-18 hours and were severe in 92.6% of subjects.
- Only one non-migraineur reported a mild headache after SB injection, suggesting a predisposition in migraineurs.
Implications:
- SB can trigger severe migraine-like headaches or exacerbate pre-existing migraines.
- SB-induced headaches may result from an imbalance between acetylcholine and other neuropeptides.
- Increased caution is recommended when administering SB due to its potential to aggravate migraines.
Related Concept Videos
01:29Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
Phenothiazines, such as prochlorperazine...
01:15Equilibrium and Balance
The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
01:30Toxidromes: Clinical Features
Toxidromes are specific patterns of symptoms resulting from toxic substance exposure. They help in the identification and treatment of poisoning. The symptoms of each toxidrome group indicate poisoning by a certain class of chemicals or drugs.1. Sympathomimetic: Stimulates the sympathetic nervous system. Symptoms include agitation, increased heart rate (HR), blood pressure (BP), respiratory rate (RR), temperature, and pupil size. Drugs like cocaine and amphetamines, along with tremors and...
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
01:24Cholinergic Antagonists: Pharmacokinetics
Cholinergic antagonists—such as antimuscarinics—are available in oral, topical, ocular, parenteral, and inhalational formulations. Most antimuscarinics are oral formulations, while scopolamine is available as a topical patch, and ipratropium and tiotropium are available as inhalation aerosols or powders. Atropine, tropicamide, and cyclopentolate are topically instilled in the eye. Most antimuscarinics are lipid-soluble and readily absorbed from the gastrointestinal tract and the conjunctiva.
01:14Increased Intracranial Pressure l: Introduction
Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...