Related Experiment Video
Updated: Jun 23, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
[Drug-eluting stents: implications for surgery patients]
S Bölükbas1, J Jähne, J Schirren
1Klinik für Thoraxchirurgie, Dr.-Horst-Schmidt-Kliniken, Ludwig-Erhard-Strasse 100, 65199 Wiesbaden, Deutschland.
Insights
Drug-eluting stents (DES) complicate surgery due to dual anti-platelet therapy, posing risks of thrombosis and bleeding. Perioperative bridging therapy is lacking, necessitating careful planning and interdisciplinary approaches.
Area of Science:
- Cardiology
- Interventional Cardiology
- Cardiovascular Surgery
Background:
- Percutaneous coronary intervention (PCI) with drug-eluting stents (DES) is crucial for coronary heart disease.
- DES necessitates at least one year of dual anti-platelet therapy (DAPT).
- DAPT presents significant challenges for patients requiring planned or emergency surgery.
Purpose of the Study:
- To highlight the clinical dilemma between stent thrombosis and perioperative bleeding in patients with DES.
- To emphasize the absence of evidence-based perioperative bridging therapy options.
- To underscore the necessity of an interdisciplinary approach and legal consultation for managing patients undergoing PCI.
Main Methods:
- Review of current clinical practices and challenges associated with DES implantation.
- Analysis of the risks and benefits of DAPT in the perioperative setting.
- Discussion of the need for coordinated care between cardiologists, surgeons, and legal experts.
Main Results:
- A significant dilemma exists between the risk of stent thrombosis and perioperative bleeding in DES patients.
- There is a lack of evidence-based bridging therapy protocols for the perioperative period.
- Surgical intervention is complicated by DAPT, raising legal and ethical concerns.
Conclusions:
- PCI with DES requires careful consideration of surgical implications and DAPT management.
- An interdisciplinary approach involving cardiologists, surgeons, and legal counsel is mandatory.
- Patients must be fully informed about the risks, benefits, and legal aspects related to DES and surgery.
Abstract:
Percutaneous coronary intervention (PCI) has a special role in the treatment of coronary heart disease. The insertion of drug-eluting stents (DES) requires dual anti-platelet therapy for at least 1 year which makes planned and emergency surgery difficult. There is a dilemma between high risk of stent thrombosis and perioperative bleeding. There is no evidence-based, bridging therapy option available perioperatively. This complex of problems should be considered whenever PCI is performed. An interdisciplinary approach is obligatory in these imminent conditions to proceed with either interventional or surgical revascularization. Co-existing malignancies and disorders which must be treated surgically should be excluded before PCI. Furthermore, DES and dual anti-platelet therapy produce unanswered forensic questions. On legal grounds it is not possible to proceed with surgery in cases of medication with anti-platelet therapy. Therefore, it is mandatory to discuss the possible answers to this problem with health care lawyers. The patient must be informed about this complex of problems.
Related Concept Videos
Aneurysm IV: Nursing Management
Peripheral Artery Disease V: Postoperative Nursing Management
Peripheral Artery Disease III: Interprofessional Care
Cardiac Catheterization I: Pre-Procedure Overview
Imaging Studies for Cardiovascular System V: CT
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...