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Updated: Jun 23, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
[Drug-eluting stents: implications for surgery patients]
S Bölükbas1, J Jähne, J Schirren
1Klinik für Thoraxchirurgie, Dr.-Horst-Schmidt-Kliniken, Ludwig-Erhard-Strasse 100, 65199 Wiesbaden, Deutschland.
Drug-eluting stents (DES) complicate surgery due to dual anti-platelet therapy, posing risks of thrombosis and bleeding. Perioperative bridging therapy is lacking, necessitating careful planning and interdisciplinary approaches.
Area of Science:
- Cardiology
- Interventional Cardiology
- Cardiovascular Surgery
Background:
- Percutaneous coronary intervention (PCI) with drug-eluting stents (DES) is crucial for coronary heart disease.
- DES necessitates at least one year of dual anti-platelet therapy (DAPT).
- DAPT presents significant challenges for patients requiring planned or emergency surgery.
Purpose of the Study:
- To highlight the clinical dilemma between stent thrombosis and perioperative bleeding in patients with DES.
- To emphasize the absence of evidence-based perioperative bridging therapy options.
- To underscore the necessity of an interdisciplinary approach and legal consultation for managing patients undergoing PCI.
Main Methods:
- Review of current clinical practices and challenges associated with DES implantation.
- Analysis of the risks and benefits of DAPT in the perioperative setting.
- Discussion of the need for coordinated care between cardiologists, surgeons, and legal experts.
Main Results:
- A significant dilemma exists between the risk of stent thrombosis and perioperative bleeding in DES patients.
- There is a lack of evidence-based bridging therapy protocols for the perioperative period.
- Surgical intervention is complicated by DAPT, raising legal and ethical concerns.
Conclusions:
- PCI with DES requires careful consideration of surgical implications and DAPT management.
- An interdisciplinary approach involving cardiologists, surgeons, and legal counsel is mandatory.
- Patients must be fully informed about the risks, benefits, and legal aspects related to DES and surgery.
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