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Related Concept Videos

Seizures l: Introduction01:20

Seizures l: Introduction

Understanding seizures and epilepsy relies on key definitions that help in recognizing, classifying, and managing these disorders. These definitions provide a framework for recognizing, classifying, and managing seizure disorders.DefinitionsA seizure is a sudden, abnormal burst of electrical activity in the brain that can cause changes in awareness, movement, sensation, or behavior, depending on the area involved. Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures,...
Seizures ll: Types01:19

Seizures ll: Types

Seizures are sudden bursts of abnormal electrical discharge in the brain that interfere with normal function. They are commonly divided into three groups: focal seizures, generalized seizures, and other types that do not fit neatly into either category.Focal SeizuresFocal seizures begin in a single brain region. When awareness is preserved, they are called focal aware seizures and may cause sensations such as tingling, unusual smells, or flashing lights. When awareness is impaired, they are...
Increased Body Temperature01:25

Increased Body Temperature

A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Types of Fever01:25

Types of Fever

Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...

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Related Experiment Video

Updated: Jun 23, 2026

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy
06:58

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy

Published on: July 12, 2021

Febrile seizures.

Leena D Mewasingh1

  • 1Imperial College Healthcare NHS Trust, London, UK.

BMJ Clinical Evidence
|May 20, 2009
PubMed
Summary
This summary is machine-generated.

This review examines treatments for simple febrile seizures in children. It found that while some treatments exist, evidence on their effectiveness and safety, particularly for preventing epilepsy, is limited.

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Area of Science:

  • Pediatrics
  • Neurology
  • Clinical Evidence

Background:

  • Simple febrile seizures affect 2-5% of children in the US/Europe and 6-9% in Japan by age 5.
  • These seizures are generalized, brief (<15 min), and occur ≤1/24h.
  • While a slight epilepsy risk exists, no adverse behavioral or cognitive effects are known.

Purpose of the Study:

  • To evaluate treatments for simple febrile seizures in children.
  • To assess the effects of fever treatments during febrile episodes.
  • To determine the impact of long-term anticonvulsant therapy and epilepsy risk reduction.

Main Methods:

  • Systematic review of 19 studies (reviews, RCTs, observational studies).
  • Searched Medline, Embase, Cochrane Library up to August 2007.
  • Included harms alerts from FDA and MHRA.

Main Results:

  • Evaluated interventions included anticonvulsants (intermittent/continuous) and antipyretics (physical, paracetamol, ibuprofen).
  • GRADE evaluation assessed the quality of evidence for interventions.
  • Data synthesized to inform clinical questions on treatment effectiveness and safety.

Conclusions:

  • The review presents information on the effectiveness and safety of various interventions for simple febrile seizures.
  • Findings guide clinical decisions regarding treatment during fever episodes and long-term management.
  • Evidence quality was assessed to provide reliable information for healthcare providers.