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Updated: May 3, 2026

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy
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A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy

Published on: July 12, 2021

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Febrile seizures

Leena D Mewasingh1

  • 1Imperial College Healthcare NHS Trust, London, UK.

BMJ Clinical Evidence
|February 4, 2014
PubMed

Insights

This review examines treatments for simple febrile seizures in children. Intermittent anticonvulsants, antipyretics, and conservative measures were evaluated for effectiveness and safety.

Area of Science:

  • Pediatrics
  • Neurology
  • Clinical Pharmacology

Background:

  • Simple febrile seizures are common, generalized seizures lasting under 10-15 minutes, occurring once every 24 hours.
  • They affect 2-9% of children globally by age 5 and do not cause permanent neurological deficits.
  • Complex febrile seizures differ in duration, symptoms, and recurrence patterns.

Purpose of the Study:

  • To systematically review the effects of treatments administered during fever episodes in children aged 6 months to 5 years with a history of simple febrile seizures.
  • To evaluate the effectiveness and safety of various interventions.

Main Methods:

  • A systematic review of randomized controlled trials (RCTs) and systematic reviews of RCTs was conducted.
  • Searches included major databases (Medline, Embase, Cochrane Library) up to July 2013.
  • Harms alerts from regulatory agencies (FDA, MHRA) were also incorporated.

Main Results:

  • Four RCTs or systematic reviews of RCTs met the inclusion criteria.
  • A GRADE evaluation was performed to assess the quality of evidence for interventions.
  • The review identified studies on intermittent anticonvulsants, antipyretics, and conservative measures.

Conclusions:

  • The review presents findings on the effectiveness and safety of intermittent anticonvulsants (clobazam, diazepam, lorazepam).
  • Antipyretic drug treatments (paracetamol, ibuprofen) were also evaluated.
  • Conservative measures, including watchful waiting and physical cooling techniques, were assessed.
Abstract

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