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Updated: Jun 23, 2026

Mouse Models Of Helicobacter Infection And Gastric Pathologies
Published on: October 18, 2018
[Helicobacter pylori in patients with disorders of hepatobiliary system]
Aim:
Detection of H. pylori in gastric mucosa, bile-excreting ducts, livertissue, and bile of patients with different disorders hepatobiliary system (HBS).
Materials And Methods:
Seventy-six patients (52 females and 24 males) with following diagnoses: chronic noncalculous cholecystitis (25 patients), gallstone disease (28), liver cirrhosis (12), ischemic heart disease (control group, n = 11), admitted to hospitals in Kazan and Zelenodolsk (Republic of Tatarstan), were examined. Mean age of the patients was 56.5 years. Samples of bile as well as tissues of liver, bile ducts and gastric mucosa were used as materials for tests. Polymerase chain reaction and culture method were used for H. pylori detection.
Results:
Analysis of obtained results showed association of clinical diagnosis and presence of H. pylori DNA in bile ducts mucosal epithelium. H. pylori was significantly more frequently detected in epithelium of bile ducts mucosa (66.7 +/- 13.6%) and bile(56 +/- 9.9%) than in liver tissue (33.3 +/- 13.6%) (p < 0.05). Rate of H. pylori detection in gastric mucosa (83.3 +/- 10.8% in patients with liver cirrhosis) correlated with its detection rate in bile ducts mucosa (66.7 +/- 13.6%). In the control group of 11 patients with ischemic heart disease H. pylori was not detected. In 16 samples of liver, bile ducts, and gastric tissues CagA-negative phenotype was observed.
Conclusion:
Presence of H. pylori in liver, bile ducts and bile could point to possible role of its microorganism in pathogenesis of hepatobiliary diseases.
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