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Fabrication of Tongue Extracellular Matrix and Reconstitution of Tongue Squamous Cell Carcinoma In Vitro
Published on: June 20, 2018
EMMPRIN expression in tongue squamous cell carcinoma
Zhiquan Huang1, Hongzhang Huang, Haigang Li
1Department of Oral and Maxillfacial Surgery, The Second Affiliated Hospital, Sun Yat-Sen University, Guangdong, China.
Summary
Extracellular matrix metalloproteinase inducer (EMMPRIN) overexpression in tongue squamous cell carcinoma correlates with advanced tumor characteristics and poor survival. This suggests EMMPRIN may be a target for immunotherapy in specific cancer patients.
Area of Science:
- Oncology
- Cancer Biology
- Immunotherapy
Background:
- Extracellular matrix metalloproteinase inducer (EMMPRIN) is a tumor-cell membrane protein stimulating matrix metalloproteinases (MMPs) production.
- Elevated EMMPRIN expression is linked to reduced survival and advanced cancer parameters.
- This study investigates EMMPRIN's role in tongue squamous cell carcinoma (TSCC).
Purpose of the Study:
- To examine the relationship between clinico-pathologic characteristics and EMMPRIN expression in TSCC.
- To determine the prognostic significance of EMMPRIN in TSCC patients.
Main Methods:
- Immunohistochemical analysis of EMMPRIN in 68 TSCC tissue specimens.
- Follow-up of patients for 1 to 119 months (average 27.5 months).
- Nonparametric tests and survival analysis to assess EMMPRIN expression and prognosis.
Main Results:
- EMMPRIN expression was significantly higher in TSCC compared to adjacent non-cancerous epithelium.
- EMMPRIN levels correlated with tumor diameter and clinical stage, but not gender, age, metastasis, or grade.
- EMMPRIN overexpression was significantly associated with poorer overall survival in TSCC patients.
Conclusions:
- EMMPRIN expression is a significant prognostic marker for overall survival in TSCC.
- EMMPRIN may serve as a potential therapeutic target for immunotherapy in a subset of TSCC patients.
