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Published on: September 18, 2018
Jaundice with hepatic dysfunction in P. falciparum malaria.
Ali Hassan Abro1, Abdulla Mahmood Ustadi, Hakim Ali Abro
1Infectious Disease Unit, Rashid Hospital, Dubai, UAE. ahabro@dohms.gov.ae
Summary
Jaundice and liver dysfunction are common in severe Plasmodium falciparum malaria, increasing complication and mortality risks. Prompt diagnosis and management are crucial for better patient outcomes.
Area of Science:
- Hepatology
- Infectious Diseases
- Parasitology
Background:
- Plasmodium falciparum malaria can cause significant hepatic dysfunction.
- Jaundice is a notable clinical manifestation of malaria-related liver injury.
Purpose of the Study:
- To determine the frequency and severity of jaundice and hepatic dysfunction in adult patients with P. falciparum malaria.
Main Methods:
- A descriptive study was conducted on 105 adult patients diagnosed with P. falciparum malaria.
- Diagnostic methods included blood film examination, comprehensive laboratory investigations (liver function tests, renal function tests, etc.), and abdominal ultrasound for patients with hepatic dysfunction.
Main Results:
- Jaundice was observed in 23% of patients. Elevated ALT levels (>3x normal) occurred in 11.4%, and serum bilirubin (>3mg/dl) in 23%.
- Patients with bilirubin >3mg/dl showed higher frequencies of elevated ALT, thrombocytopenia, anemia, and renal impairment.
- A mortality rate of 4.7% was recorded, with higher mortality observed in patients with bilirubin levels >3mg/dl.
Conclusions:
- Hepatic dysfunction in P. falciparum malaria varies from mild enzyme elevation to acute hepatitis.
- Significant hepatic dysfunction is associated with severe illness, increased complications, and higher mortality rates.
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