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Implantation of Left Ventricular Assist Device (LVAD) in Juvenile Landrace Swine: A LVAD Implantation Model of Pediatric Heart Failure

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Published on: January 16, 2026

Implantable left ventricular assist system.

Chisato Nojiri¹

¹Terumo Heart, Inc, Ann Arbor, MI 48103-9140, USA. chisato.nojiri@terumomedical.com

Circulation Journal : Official Journal of the Japanese Circulation Society

|June 6, 2009

Summary

First-generation pulsatile implantable left ventricular assist systems (LVAS) advanced heart failure treatment but faced limitations. Newer rotary blood pump LVAS aim to overcome these challenges, improving therapeutic options.

Area of Science:

Cardiovascular Surgery
Biomedical Engineering
Medical Devices

Background:

The first-generation pulsatile implantable left ventricular assist system (LVAS) became a key therapy for advanced heart failure by the mid-1980s, serving as a bridge to transplantation.
Despite its success, this technology presented significant limitations, including high rates of thromboembolic complications, infection, mechanical failures, and large device size.

Purpose of the Study:

To review the historical development of implantable left ventricular assist systems (LVAS).
To discuss the current status and advancements in LVAS technology.
To highlight the transition from first-generation pulsatile devices to newer rotary blood pump systems.

Main Methods:

Historical review of implantable left ventricular assist system (LVAS) development.

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Analysis of clinical outcomes and technological limitations of first-generation pulsatile LVAS.

Examination of the emergence and progress of second-generation rotary blood pump LVAS.

Main Results:

First-generation pulsatile LVAS significantly advanced heart failure treatment but were associated with notable complications and design drawbacks.
Technological limitations of pulsatile LVAS spurred the development of smaller, potentially more reliable rotary blood pump LVAS.
Rotary blood pump LVAS represent the next stage in LVAS evolution, with ongoing development and clinical application.

Conclusions:

Implantable left ventricular assist systems (LVAS) have evolved from experimental treatments to established therapies for advanced heart failure.
Ongoing innovation in LVAS technology, particularly with rotary blood pumps, aims to mitigate the shortcomings of earlier generations.
The field of mechanical circulatory support continues to advance, offering improved options for patients with end-stage heart failure.