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Updated: Jun 22, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Cleft lip and/or palate and breathing during sleep
Joanna E MacLean1, Peter Hayward, Dominic A Fitzgerald
1Discipline of Paediatrics & Child Health, Faculty of Medicine, University of Sydney, NSW, Australia. JoannaM4@med.usyd.edu.au
Infants and children with cleft lip and/or palate (CL/P) face higher risks of sleep disordered breathing (SDB) due to anatomical changes. This review explores the causes, risks, and treatments for SDB in this population.
Area of Science:
- Craniofacial anomalies
- Pediatric sleep medicine
- Respiratory health
Background:
- Cleft lip and/or palate (CL/P) is a common congenital condition.
- CL/P is associated with significant changes in facial structures, including a smaller upper airway.
- These anatomical alterations predispose affected infants and children to an increased risk of sleep disordered breathing (SDB).
Purpose of the Study:
- To review the anatomical and functional factors contributing to SDB risk in pediatric CL/P.
- To define the magnitude of SDB risk in infants and children with CL/P.
- To present current treatment information and discuss future research directions for SDB in this population.
Main Methods:
- Literature review of anatomical and functional factors in CL/P.
- Synthesis of existing research on SDB prevalence and severity in pediatric CL/P.
- Compilation of treatment strategies and identification of research gaps.
Main Results:
- Infants and children with CL/P exhibit specific craniofacial and airway characteristics that elevate SDB risk.
- The literature indicates a substantial increase in SDB incidence and severity among children with CL/P compared to the general pediatric population.
- Evidence-based treatment options for SDB in this cohort are emerging but require further investigation.
Conclusions:
- Pediatric CL/P presents unique challenges that significantly increase the risk of SDB.
- Early identification and management of SDB are crucial for the health and development of children with CL/P.
- Further research is needed to optimize SDB treatment protocols and long-term outcomes for individuals with CL/P.
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