Related Experiment Video
Updated: Jun 22, 2026
10:45
In Situ Visualization of Axon Growth and Growth Cone Dynamics in Acute Ex Vivo Embryonic Brain Slice Cultures
Published on: October 14, 2021
Axons find their way in the snow
1University of California, San Diego, La Jolla, CA 92093, USA. yzou@ucsd.edu
Development (Cambridge, England)
|June 9, 2009
Summary
Researchers explored molecular cues for axonal connections, development, and regeneration. Joint sessions with neurodegenerative disease experts fostered discussions on axon degeneration and neural stem cells.
Area of Science:
- Neuroscience
- Developmental Biology
Background:
- The 2009 Keystone Symposium convened experts to discuss molecular mechanisms underlying neural development and regeneration.
- The meeting focused on critical areas including axon guidance, synapse formation, dendrite development, and axon regeneration.
Framework:
- The symposium provided a platform for interdisciplinary exchange on the latest research findings.
- Joint sessions with the Neurodegenerative Diseases symposium facilitated cross-field dialogue.
Implementation:
- Discussions covered topics such as axon guidance molecules, synaptic plasticity, and cellular mechanisms of regeneration.
- The event facilitated the sharing of novel techniques and experimental approaches in neuroscience.
Implications:
- Advancements in understanding axonal connections are crucial for addressing developmental disorders and neurodegenerative diseases.
- The collaborative environment is expected to spur future research into neural repair and regeneration strategies.
Related Concept Videos
01:21Neurons: The Axon
Axons are long, cytoplasmic processes of nerve cells capable of propagating electrical impulses known as action potentials. The cytoplasm or axoplasm of an axon contains neurofibrils, neurotubules, small vesicles, lysosomes, mitochondria, and various enzymes, all encased within the axolemma, the plasma membrane of the axon.
The axon attaches to the cell body at a cone-shaped elevation called the axon hillock. The initial part of the axon, closest to the hillock, is known as the initial segment.
The axon attaches to the cell body at a cone-shaped elevation called the axon hillock. The initial part of the axon, closest to the hillock, is known as the initial segment.
01:10Spinal Cord: Information Processing
The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
01:41Action Potentials
Overview
01:14Action Potential
Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
01:14Action Potential
Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
01:25Nervous Tissue: Myelin
The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...