Related Experiment Video
Updated: Jun 22, 2026
09:39
Mapping Dysfunctional Protein-Protein Interactions in Disease
Published on: October 24, 2025
DASMIweb: online integration, analysis and assessment of distributed protein interaction data
Hagen Blankenburg1, Fidel Ramírez, Joachim Büch
1Max Planck Institute for Informatics, Campus E1.4, 66123 Saarbrücken, Germany. hagen.blankenburg@mpi-inf.mpg.de
Nucleic Acids Research
|June 9, 2009
Summary
The DASMIweb server integrates distributed protein interaction data, simplifying access for biologists. It enables efficient querying and qualitative assessment of multiple interaction sources in one place.
Area of Science:
- Bioinformatics
- Computational Biology
- Systems Biology
Background:
- The volume of available protein interaction data has significantly increased.
- Data is often fragmented across numerous online repositories, hindering accessibility for biologists.
- A unified platform is needed to consolidate and analyze this dispersed information.
Purpose of the Study:
- To develop a web server for integrating and analyzing distributed protein interaction data.
- To provide biologists with a single, dynamic site for accessing interaction information.
- To facilitate interactome studies by simplifying data retrieval and assessment.
Main Methods:
- Development of the DASMIweb server.
- Integration of multiple online repositories for protein and domain interactions.
- Implementation of configurable resource pools and inclusion of confidence measures (e.g., functional similarity scores).
- Support for exporting results in standard formats like MITAB and SIF.
Main Results:
- DASMIweb successfully integrates and allows dynamic analysis of scattered protein interaction data.
- The server enables simultaneous querying of diverse interaction resources, minimizing user effort.
- Confidence measures are integrated to aid in the qualitative assessment of individual interactions.
Conclusions:
- DASMIweb serves as a crucial starting point for interactome studies.
- The platform enhances the accessibility and usability of public protein interaction data.
- It empowers biologists with efficient tools for exploring complex interaction networks.
Related Concept Videos
02:26Protein Networks
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
02:04Protein-protein Interfaces
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...