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Updated: Jun 22, 2026
08:20
A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
Published on: October 2, 2018
[Case of complete androgen insensitivity syndrome]
Kojiro Ohba1, Yasushi Hayashida, Hironobu Hakariya
1Department of Urology, National Hospital Organization Ureshino Medical Center.
Hinyokika Kiyo. Acta Urologica Japonica
|June 11, 2009
Summary
This case study details a 23-year-old female diagnosed with complete androgen insensitivity syndrome (CAIS). The patient underwent gonadectomy and is now receiving estrogen replacement therapy for primary amenorrhea.
Area of Science:
- Endocrinology
- Genetics
- Gynecology
Background:
- Primary amenorrhea in individuals with 46,XY karyotype suggests disorders of sex development.
- Androgen insensitivity syndrome (AIS) is a condition where individuals with XY chromosomes are resistant to male hormones.
Observation:
- A 23-year-old patient presented with primary amenorrhea, good breast development, sparse pubic hair, and a blind-ending vagina.
- Hormone levels revealed elevated testosterone and normal gonadotropins, with a 46,XY karyotype.
- Bilateral inguinal gonads were identified, with absence of uterus and ovaries.
Findings:
- The patient was diagnosed with complete androgen insensitivity syndrome (CAIS).
- Bilateral gonadectomy was successfully performed.
- Post-operative management included estrogen replacement therapy.
Implications:
- This case highlights the importance of timely diagnosis and management of CAIS.
- Estrogen therapy is crucial for maintaining female secondary sexual characteristics and overall health in CAIS patients.
- Understanding CAIS is vital for genetic counseling and reproductive health planning.
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