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Poly(Hpma)-coated liposomes demonstrate prolonged circulation in mice.
K R Whiteman1, V Subr, K Ulbrich
1Department of Pharmaceutical Sciences, Northeastern University, 360 Huntington Ave, Boston, MA, 02115, U.S.A.
Journal of Liposome Research
|June 18, 2009
Summary
Surface modification using poly[N-(2-hydroxypropyl)methacrylamide] (poly(HPMA)) polymers enhances liposome circulation time. These modified liposomes show reduced uptake by the reticuloendothelial system (RES), indicating potential for improved drug delivery systems.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Pharmaceutics
Background:
- Liposome surface modification with polymers like polyethylene glycol (PEG) prolongs circulation time and reduces reticuloendothelial system (RES) uptake.
- Exploring alternative polymers is crucial for expanding the properties of long-circulating liposomes.
Purpose of the Study:
- To synthesize and evaluate poly[N-(2-hydroxypropyl)methacrylamide] (poly(HPMA)) polymers for liposome surface modification.
- To assess the efficacy of poly(HPMA)-modified liposomes as a long-circulating drug delivery system.
Main Methods:
- Synthesis of semitelechelic poly(HPMA) with oleic acid hydrophobic termini.
- Incorporation of poly(HPMA) onto liposomes composed of phosphatidylcholine and cholesterol.
- In vivo evaluation of liposome circulation time and liver accumulation in mice.
Main Results:
- Poly(HPMA)-modified liposomes demonstrated significant steric protection.
- Enhanced circulation times were observed for the modified liposomes in experimental mice.
- Reduced accumulation in the liver was noted for poly(HPMA)-modified liposomes.
Conclusions:
- Poly(HPMA) is an effective polymer for surface modification of liposomes, providing steric stabilization.
- Poly(HPMA)-modified liposomes represent a promising alternative for developing long-circulating drug delivery systems.
