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Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

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Published on: June 7, 2015

Algorithm and simulation for real-time positron emission based tumor tracking using a linear fiducial marker.

Nathan W Churchill¹, Marc Chamberland, Tong Xu

¹Department of Physics, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada.

Medical Physics

|June 24, 2009

Summary

Accurate radiotherapy requires real-time tumor tracking. A new linear positron emitter tracking method offers submillimeter accuracy and precise orientation, improving cancer treatment delivery.

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Area of Science:

Medical Physics
Radiotherapy Technology
Nuclear Medicine Imaging

Background:

Radiotherapy effectiveness is limited by precise tumor dose delivery.
Real-time tumor localization during therapy is crucial for improved outcomes.
Current methods using point sources pose potential patient complications.

Purpose of the Study:

To propose and evaluate a less invasive linear source geometry for real-time tumor tracking.
To develop and test a novel source localization algorithm for improved tracking precision.
To assess the feasibility of this method for clinical radiotherapy applications.

Main Methods:

Utilized Monte Carlo simulations with the Geant4 application for emission tomography (GATE) package.
Developed a source localization algorithm based on cost-function minimization of annihilation gamma coincidence lines.
Simulated a linear source of 2.00 cm length and 0.1 mm width.

Main Results:

Submillimeter accuracy in locating the linear marker midpoint was achieved with 200 coincidence events.
Source orientation was determined with less than 5 degrees angular deviation at 300 events.
At 700 events, mean midpoint error was 0.48 +/- 0.26 mm and mean angular deviation was 1.4 +/- 0.8 degrees.

Conclusions:

The proposed linear source geometry is a less invasive alternative to point sources.
The developed localization algorithm provides high precision for tracking implanted positron emitters.
This tracking system shows potential for effective clinical implementation in radiotherapy.