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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
Tuberculosis into the 2010s: is the glass half full?
Anna P Ralph1, Nicholas M Anstey, Paul M Kelly
1International Health Division, Menzies School of Health Research, PO Box 41096, Casuarina NT 0811, Australia. annaralph@bigpond.com
Summary
Significant advancements in tuberculosis diagnostics, drugs, and treatment strategies have emerged, alongside new challenges like extensively drug-resistant TB. Updates to care standards and optimized programs offer hope for improved global tuberculosis control.
Area of Science:
- Global Health
- Infectious Diseases
- Public Health Policy
Background:
- Tuberculosis (TB) remains a global emergency, complicated by extensively drug-resistant (XDR-TB) strains and co-infection with human immunodeficiency virus (HIV).
- Over 16 years, progress has been made despite emerging challenges, necessitating an update to existing care standards.
Purpose of the Study:
- To review advancements in TB diagnostics, therapeutics, and control strategies since TB was declared a global emergency.
- To propose updates to the International Standards of Tuberculosis Care to incorporate recent developments.
- To advocate for optimized control programs and increased political will.
Main Methods:
- Literature review and synthesis of advancements in TB diagnostics and drug development.
- Analysis of treatment outcomes for multidrug-resistant TB (MDR-TB) and XDR-TB.
- Evaluation of strategies for managing co-infections and nosocomial transmission.
Main Results:
- Improvements in TB diagnostics and a pipeline of new candidate drugs.
- Enhanced treatment outcomes for MDR-TB and XDR-TB.
- Increased recognition of nosocomial transmission and improved HIV-TB co-infection management.
Conclusions:
- Recent scientific and programmatic achievements provide a basis for improved TB control.
- Updating the International Standards of Tuberculosis Care is crucial.
- Optimized directly observed treatment, short course (DOTS) programs, political will, and widespread deployment are essential for enhanced global TB control.
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