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ADAM9 as a potential target molecule in cancer
1Institut Pasteur, Laboratory of Lymphoid Tissue Development, CNRS URA1961, Paris, France. pedutol@pasteur.fr
Current Pharmaceutical Design
|July 16, 2009
Summary
ADAM9 protein is overexpressed in cancers and sheds molecules crucial for tumor growth and blood vessel formation, making it a potential therapeutic target for cancer treatment.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- ADAM (a disintegrin and metalloproteinase) proteins mediate ectodomain shedding of membrane-bound molecules.
- ADAMs are critical regulators of cell signaling in development, homeostasis, and disease, including cancer.
- ADAM9 is frequently overexpressed in human cancers and implicated in tumorigenesis.
Purpose of the Study:
- To review the role of ADAM9 in tumorigenesis.
- To discuss ADAM9's function in shedding cell surface molecules relevant to cancer.
- To explore emerging aspects of ADAM9 regulation and its functions in cancer development.
Main Methods:
- Literature review focusing on ADAM9's role in cancer.
- Analysis of ADAM9's substrates and their involvement in tumorigenesis and angiogenesis.
- Discussion of potential therapeutic targeting of ADAM9 in cancer.
Main Results:
- ADAM9 cleaves and releases key molecules like EGF, FGFR2iiib, Tie-2, Flk-1, EphB4, CD40, VCAM-1, and VE-cadherin.
- These cleaved molecules play significant roles in tumor growth and angiogenesis.
- ADAM9's overexpression correlates with cancer progression.
Conclusions:
- ADAM9 is a significant contributor to tumorigenesis through the shedding of critical substrates.
- ADAM9 represents a promising therapeutic target for various human cancers.
- Further research into ADAM9 regulation and function is warranted for cancer therapy development.
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