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Related Concept Videos

Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...

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Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder
11:17

Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder

Published on: November 25, 2025

Deep brain stimulation in obsessive-compulsive disorder.

Damiaan Denys1, Mariska Mantione

  • 1Department of Psychiatry, AMC, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands. d.denys@amc.nl

Progress in Brain Research
|August 8, 2009
PubMed
Summary
This summary is machine-generated.

Deep brain stimulation (DBS) shows promise for treating obsessive-compulsive disorder (OCD), with preliminary results indicating significant symptom reduction. While side effects are usually temporary, DBS for OCD remains experimental due to limited studies.

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Area of Science:

  • Neurology
  • Psychiatry
  • Neurosurgery

Background:

  • Deep brain stimulation (DBS) is gaining traction for psychiatric disorders due to its low risk, reversibility, and adjustable parameters.
  • Current investigations focus on DBS for obsessive-compulsive disorder (OCD), Gilles de la Tourette's syndrome, and major depression.

Purpose of the Study:

  • This chapter reviews the application of deep brain stimulation (DBS) specifically for obsessive-compulsive disorder (OCD).

Main Methods:

  • Review of existing studies on deep brain stimulation for obsessive-compulsive disorder.
  • Analysis of preliminary results regarding efficacy and side effects.

Main Results:

  • Preliminary findings suggest DBS can reduce OCD symptoms by 40-60% in over half of patients.
  • Observed side effects are typically transient and manageable by adjusting stimulation parameters.

Conclusions:

  • Deep brain stimulation (DBS) shows potential as an effective treatment for obsessive-compulsive disorder (OCD).
  • Further research with larger patient cohorts and standardized protocols is necessary to establish DBS for OCD as a definitive treatment.
  • The rapid effects of DBS offer insights into the underlying pathophysiology of OCD.