[The systemic and regional changes in the modelling of a massive pulmonary artery embolism]

In anesthetized dogs with natural breathing, embolisation of pulmonary arterial bed increased systolic pressure in the right ventricle of the heart up to 60.0-113.0 mm Hg. Within 6 hrs the pressure far exceeded initial and control parameters in the minor circulation circle. Tachycardia and tachypnea as well as a reduction of the left ventricle contractions and a decrease of arterial pressure occurred. The massive emboli was followed by an obvious hypoxia and an insignificant hypocapnia with no essential shifts in the blood acid-base balance. Subsequent interstitial oedema of pulmonary tissue may be due both to the changes in the lung hemodynamics and to direct damaging of endothelium in the microvessels.