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Published on: May 22, 2020
Stimulus-responsive targeted nanomicelles for effective cancer therapy
Madaswamy S Muthu1, Chellappa V Rajesh, Amit Mishra
1Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221005, India. muthubits@rediffmail.com
Stimulus-responsive nanomicelles offer targeted anticancer drug delivery to overcome challenges like multidrug resistance. This review highlights advancements, toxicity, and future perspectives in nanomedicine for effective cancer treatment.
Area of Science:
- Nanomedicine
- Polymer Chemistry
- Oncology
Background:
- Nanotechnology has yielded innovative nanomedicines.
- Nanomicelles, block copolymer self-assemblies, are key for targeted drug delivery and imaging.
- Stimulus-responsive nanomicelles release drugs based on internal or external triggers.
Purpose of the Study:
- Review recent advancements in stimulus-responsive targeted nanomicelles for cancer therapy.
- Address challenges in cancer treatment, such as multidrug resistance.
- Discuss toxicity and future outlook of nanomicelles.
Main Methods:
- Focus on the design of stimulus-responsive targeted nanomicelles.
- Incorporate anticancer drugs for targeted delivery.
- Analyze recent literature on nanomicelle advancements.
Main Results:
- Nanomicelles show promise in overcoming cancer cell resistance.
- Stimuli-responsive systems enhance drug release precision.
- Advancements focus on improving efficacy and reducing side effects.
Conclusions:
- Stimulus-responsive nanomicelles are a promising strategy for effective cancer treatment.
- Further research is needed to address toxicity and optimize nanomicelle design.
- Nanomedicine offers a future perspective for personalized cancer therapy.
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