Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Antibiotic Selection00:57

Antibiotic Selection

Overview
Mismatch Repair01:36

Mismatch Repair

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Projected impact of a pathogen reduction intervention on carbapenem-resistant Enterobacterales bloodstream infections and deaths in the United States.

Infection control and hospital epidemiology·2026
Same author

Modification of antimicrobial susceptibility testing methods.

The Journal of antimicrobial chemotherapy·2025
Same author

Environmental and Health Care Personnel Sampling and Unobserved Clostridium difficile Transmission in ICU.

JAMA network open·2025
Same author

Antimicrobial-Resistant Infections in Hospitalized Patients.

JAMA network open·2025
Same author

Expanding the use of mathematical modeling in healthcare epidemiology and infection prevention and control.

Infection control and hospital epidemiology·2024
Same author

Measuring the Direct Medical Costs of Hospital-Onset Infections Using an Analogy Costing Framework.

PharmacoEconomics·2024
Same journal

Reconsidering ambiguous language in infectious disease consult recommendations.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Antibiotic Treatment Duration for Uncomplicated Monomicrobial Enterococcal Bloodstream Infection: A Multicenter Target Trial Emulation.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Larger Blood Volume Increases Detection of Fastidious Mycobacteria and Fungi in Blood Culture.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Anticalcitonin: Limited utility of a context-dependent biomarker demonstrated in another real-world data set.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Procalcitonin Testing in Community-Acquired Pneumonia.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Wanted: A Relevant Correlate of Protection for Dengue Vaccines.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
See all related articles

Related Experiment Video

Updated: Jun 21, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

Mupirocin resistance.

Jean B Patel1, Rachel J Gorwitz, John A Jernigan

  • 1Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. jpatel1@cdc.gov

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|August 14, 2009
PubMed
Summary
This summary is machine-generated.

Increased mupirocin use for methicillin-resistant Staphylococcus aureus (MRSA) nasal decolonization may drive resistance. Understanding mupirocin resistance mechanisms is crucial for effective MRSA control strategies.

Related Experiment Videos

Last Updated: Jun 21, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Rising MRSA infections necessitate effective decolonization strategies.
  • Mupirocin is a key agent for nasal decolonization of MRSA.
  • Increased mupirocin use may impact resistance development.

Purpose of the Study:

  • To review mechanisms and clinical significance of mupirocin resistance in Staphylococcus aureus.
  • To understand the epidemiology of mupirocin resistance.
  • To inform strategies for monitoring mupirocin resistance.

Main Methods:

  • Literature review of studies on mupirocin resistance mechanisms.
  • Analysis of data on mupirocin resistance rates and their correlation with usage.
  • Discussion of diagnostic methods for mupirocin resistance.

Main Results:

  • High-level mupirocin resistance in S. aureus is primarily mediated by the plasmid-encoded mupA gene.
  • The mupA gene can be located on conjugative plasmids carrying multiple resistance determinants.
  • High-level resistance is linked to decolonization failure, and resistance rates increase with mupirocin use.
  • Low-level resistance involves mutations in the native ileS gene, with unclear clinical significance.

Conclusions:

  • Widespread mupirocin use for MRSA decolonization requires careful consideration of resistance.
  • Monitoring mupirocin resistance is essential to maintain its efficacy.
  • Institutions should develop strategies to track resistance and mitigate its impact on MRSA control.