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Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Antimicrobial evaluation of imines and thiazolidinones derived from 3-phenylpropane hydrazide
Neeraj K Fuloria1, Vijender Singh, Mohammad Shahar Yarb
1Department of Pharmacy, Rameesh Institute of Vocational and Technical Education, 3-Knowledge park-1, Kasna road, Greater NOIDA, India. nfuloria@rediffmail.com
Abstract:
Methyl 3-phenylpropanoate (1), after hydrazination into 3-phenylpropanehydrazide (2), was converted into N-arylidene-3-phenylpropane hydrazides (3a-e), which on cyclization with thioglycolic acid yielded N-(4-oxo-2-arylthiazolidin-3-yl)-3-phenylpropanamides (4a-e). All the proposed structures of newly synthesized compounds were in full agreement with the spectral data. Due to para substitution, compound 3a, 4a and 4b were found to be the most potent when evaluated for antibacterial and antifungal activities.
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