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Updated: Jun 20, 2026

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
Published on: July 5, 2021
Imaging of the central skull base
1Radiology Departement, Instituto Português de Oncologia de Francisco Gentil- Centro de Lisboa, 1093, Lisboa, Portugal. borgalexandra@gmail.com
This review details the complex central skull base (CSB) anatomy and pathology. It emphasizes cross-sectional imaging for diagnosing and managing CSB lesions through an anatomic approach.
Area of Science:
- Radiology
- Anatomy
- Pathology
Background:
- The central skull base (CSB) is an intricate anatomical region connecting the extracranial head and neck with the middle cranial fossa.
- It contains numerous foramina and canals housing critical neurovascular structures, serving as potential pathways for disease spread.
- Lesions in the CSB can originate intrinsically, intracranially, or extracranially.
Purpose of the Study:
- To provide a systematic, anatomy-based approach for evaluating central skull base lesions.
- To highlight the indispensable role of cross-sectional imaging in the diagnosis, treatment planning, and follow-up of CSB pathologies.
Main Methods:
- Review of the complex anatomy of the central skull base.
- Discussion of potential origins and spread patterns of CSB lesions.
- Emphasis on cross-sectional imaging techniques.
Main Results:
- A systematic approach to CSB evaluation based on its major tissue constituents is presented.
- Cross-sectional imaging is crucial for comprehensive assessment of CSB lesions.
- Understanding the anatomical relationships is key to identifying lesion origin and extent.
Conclusions:
- A structured, anatomical approach aids in the effective diagnosis and management of central skull base lesions.
- Cross-sectional imaging is essential for delineating the complex CSB and associated pathologies.
- This review offers a framework for radiologists and clinicians managing CSB diseases.
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