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Updated: Jun 20, 2026
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Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing
Published on: February 10, 2023
Multipyrene tandem probes for detection of C677T polymorphism in MTHFR gene
Svetlana A Kholodar1, Daria S Novopashina, Mariya I Meschaninova
1Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk 630090, Russia. danov@niboch.nsc.ru
Nucleic Acids Symposium Series (2004)
|September 15, 2009
Abstract:
We designed tandems of oligo(2'-O-methylribonucleotides) conjugates containing two bispyrene (5'-bisPyr and 3'-bisPyr) groups on their junction for detection of C677T polymorphism in the methylenetetrahydrofolate reductase gene (MHTFR). The potential of SNP detection with multipyrene tandems of oligo(2'-O-methylribonucleotides) was demonstrated.
