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Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
Pedigree Analysis01:35

Pedigree Analysis

Overview

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Related Experiment Video

Updated: Jun 20, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

Hereditary prothrombin deficiency.

Muzamil Shabana Ejaz1, Nazia Latif, Ashraf Memon

  • 1Department of Pediatrics, Civil Hospital, Karachi.

JPMA. the Journal of the Pakistan Medical Association
|September 16, 2009
PubMed
Summary

Hereditary prothrombin deficiency, a rare bleeding disorder, was diagnosed in a 4-month-old infant presenting with sepsis and later bruising. Prothrombin levels were absent, confirming the diagnosis.

Area of Science:

  • Hematology
  • Pediatrics
  • Genetics

Background:

  • Hereditary prothrombin deficiency is a rare inherited bleeding disorder.
  • It affects the common pathway of the coagulation cascade.
  • Diagnosis can be challenging due to non-specific initial symptoms.

Purpose of the Study:

  • To report a case of hereditary prothrombin deficiency in an infant.
  • To highlight diagnostic challenges and clinical presentation.
  • To emphasize the importance of coagulation screening in infants with bleeding symptoms.

Main Methods:

  • Clinical case presentation.
  • Review of patient's medical history and symptoms.
  • Coagulation profile analysis, including prothrombin level assessment.

More Related Videos

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
08:01

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

Published on: February 27, 2026

Related Experiment Videos

Last Updated: Jun 20, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
08:01

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

Published on: February 27, 2026

Main Results:

  • A 4-month-old infant initially presented with symptoms of meningitis and sepsis.
  • The infant was later readmitted with bruising, indicating a potential bleeding disorder.
  • Coagulation tests revealed an absent prothrombin level, confirming hereditary prothrombin deficiency.

Conclusions:

  • Hereditary prothrombin deficiency can present with severe symptoms in infancy.
  • Early recognition and diagnosis are crucial for effective management.
  • This case underscores the importance of comprehensive coagulation testing in pediatric bleeding disorders.