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Updated: Jun 20, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
A delicate balance between sp2 and sp3 C-H bond activation: a Pt(II) complex with a dual agostic interaction
Sarah H Crosby1, Guy J Clarkson, Jonathan P Rourke
1Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK.
Abstract:
2-tert-Butyl-6-(4-fluorophenyl)pyridine reacts with K(2)PtCl(4) via the activation of an sp(2) C-H bond to give a cyclometalated complex that contains a bifurcated agostic interaction. Rearrangement of this complex results in the activation of an sp(3) C-H bond, and reaction eventually leads to a doubly cyclometalated complex where both sp(2) and sp(3) C-H bonds have been activated. Deuterium exchange studies show that a delicate balance exists between the two cyclometalations.
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