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Updated: Jun 20, 2026
06:15
Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Topical chemotherapy for ocular surface squamous neoplasia: current status
Ricardo Sepulveda1, Jacob Pe'er, Edoardo Midena
1Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
The British Journal of Ophthalmology
|September 25, 2009
Summary
Topical mitomycin-C, 5-fluorouracil, and interferon-alpha2b show similar efficacy for ocular surface squamous neoplasia. 5-Fluorouracil is recommended due to its lower cost and fewer side effects.
Area of Science:
- Ophthalmology
- Oncology
Background:
- Non-invasive ocular surface squamous neoplasia (OSSN) is a premalignant condition.
- Topical chemotherapeutic agents are used for OSSN treatment.
Purpose of the Study:
- To compare the efficacy of topical mitomycin-C, 5-fluorouracil, and interferon-alpha2b for OSSN.
- To identify the preferred agent based on efficacy, side effects, and cost.
Main Methods:
- Review of published studies comparing topical mitomycin-C, 5-fluorouracil, and interferon-alpha2b.
- Analysis of reported efficacy rates (80%-88%) for OSSN treatment.
Main Results:
- No randomized trials directly compare these agents.
- Published studies suggest comparable efficacy across all three agents.
Conclusions:
- Mitomycin-C, 5-fluorouracil, and interferon-alpha2b are equally effective for OSSN.
- 5-Fluorouracil may be the preferred agent due to a lower incidence of serious side effects and reduced patient cost.
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