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Bioanalysis of anti-ulcer agents
1Department of Pharmacy and Pharmaceutics, Virginia Commonwealth University, Richmond 23298.
Journal of Chromatography
|October 12, 1990
Summary
Analytical methods for anti-ulcer drugs show a shift towards solid-phase extraction, offering faster, cheaper, and more efficient sample preparation. Future trends include more sensitive detection techniques for potent drugs.
Area of Science:
- Analytical Chemistry
- Pharmacology
Background:
- Traditional liquid-liquid extraction is predominant for anti-ulcer drug analysis.
- Liquid chromatography is favored over gas chromatography for nanogram-range analytes.
Purpose of the Study:
- To review analytical methods for anti-ulcer drugs.
- To identify trends and future directions in drug analysis.
Main Methods:
- Review of analytical methodologies.
- Analysis of trends in extraction and detection techniques.
Main Results:
- Increasing utilization of solid-phase extraction (SPE) techniques.
- Continued predominance of liquid-liquid extraction (LLE) methods.
- Preference for liquid chromatography (LC) over gas chromatography (GC).
Conclusions:
- SPE is expected to increase due to efficiency and cost benefits.
- More sensitive detection methods (electrochemical, chemiluminescence) are anticipated for potent drugs at low concentrations.