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Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

Overview
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...

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Related Experiment Video

Updated: Jun 19, 2026

Evaluating Therapeutic and Chemical Toxicity Using Organ-Cultured Porcine Corneas and Epithelial Wound Healing
03:57

Evaluating Therapeutic and Chemical Toxicity Using Organ-Cultured Porcine Corneas and Epithelial Wound Healing

Published on: January 10, 2025

Ketoprofen allergic reactions.

Carmen Cantisani1, Teresa Grieco, Valentina Faina

  • 1Department of Dermatology and Plastic Surgery, University Sapienza of Rome, vle del Policlinico 155, 00161; Rome, Italy. carmencantisanister@gmail.com

Recent Patents on Inflammation & Allergy Drug Discovery
|October 17, 2009
PubMed
Summary
This summary is machine-generated.

Topical ketoprofen (KP) use is rising, leading to more photoallergic contact dermatitis cases. Research explores cross-reactivity with similar substances, highlighting the need for further investigation into this condition.

Related Experiment Videos

Last Updated: Jun 19, 2026

Evaluating Therapeutic and Chemical Toxicity Using Organ-Cultured Porcine Corneas and Epithelial Wound Healing
03:57

Evaluating Therapeutic and Chemical Toxicity Using Organ-Cultured Porcine Corneas and Epithelial Wound Healing

Published on: January 10, 2025

Area of Science:

  • Dermatology
  • Pharmacology
  • Allergology

Background:

  • Topical ketoprofen (KP) is a common anti-inflammatory medication.
  • Increased usage of topical ketoprofen has correlated with a rise in reported photoallergic contact dermatitis (PACD).

Purpose of the Study:

  • To review literature on cross-sensitization patterns in patients with ketoprofen-induced PACD.
  • To evaluate cross-reactivity with structurally similar chemicals, sunscreens, and fragrance components.
  • To assess the occurrence of prolonged photosensitivity.

Main Methods:

  • Literature review evaluating reported cases of ketoprofen-induced photoallergic contact dermatitis.
  • Analysis of cross-reactivity and concomitant sensitization.
  • Review of patents for alternative treatments.

Main Results:

  • The study identified an increase in ketoprofen-induced photoallergic contact dermatitis.
  • Cross-sensitization with various agents, including sunscreens and fragrances, was observed.
  • Distinguishing true cross-reactivity from concomitant sensitization presents a challenge.

Conclusions:

  • Further research is essential to fully understand the complexities of ketoprofen-induced photoallergic contact dermatitis and cross-reactivity.
  • The findings underscore the importance of considering alternative treatments for musculoskeletal diseases and NSAID-induced allergies.