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JAK3 inhibitors in organ transplantation and autoimmune disease

Zuquan Xiong1, Anlun Ma, Huifang Chen

  • 1Laboratory of Experimental Surgery, Department of Surgery, Research Centre, Centre hospitalier de l'Université de Montréal (CHUM), Hôpital Notre-Dame, and Université de Montréal, Montreal, Quebec, Canada.

Recent Patents on Inflammation & Allergy Drug Discovery
|October 17, 2009
PubMed

Janus kinase 3 (JAK3) is a cytoplasmic tyrosine kinase associated with the common gamma chain that is activated by multiple T-cell growth factors including IL-2, -4, -9, -15, and -21. From the recent reports, genetic absence or ablation of JAK3 is associated with defective T-cell immunity that results in severe combined immunodeficiency (SCID) and pharmacological inhibition has prolonged allograft survival in some models of organ transplantation. This review would provide an overview of some patents along with the role of JAK3 in the immune system and efficacy of JAK3 inhibitors in experimental allograft rejection and autoimmune disease.

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