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Updated: Jun 19, 2026

Using Enzyme-based Biosensors to Measure Tonic and Phasic Glutamate in Alzheimer's Mouse Models
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Using Enzyme-based Biosensors to Measure Tonic and Phasic Glutamate in Alzheimer's Mouse Models

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Optimized glutamate detection at 3T.

Ileana Hancu1

  • 1GE Global Research Center, Niskayuna, New York 12309, USA. hancu@crd.ge.com

Journal of Magnetic Resonance Imaging : JMRI
|October 27, 2009
PubMed
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This study compared magnetic resonance imaging (MRI) pulse sequences for measuring brain glutamate (Glu) concentration. A Carr-Purcell PRESS (CPRESS) sequence demonstrated the most repeatable Glu measurements in vivo at 3T.

Area of Science:

  • Neuroimaging
  • Magnetic Resonance Spectroscopy (MRS)

Background:

  • Accurate quantification of brain metabolites like glutamate (Glu) is crucial for understanding neurological function and disease.
  • Proton Magnetic Resonance Spectroscopy (1H-MRS) at 3 Tesla (3T) is a powerful tool for in vivo metabolite measurement.

Purpose of the Study:

  • To identify optimal pulse sequences and acquisition parameters for accurate and repeatable in vivo measurement of brain glutamate concentration at 3T.
  • To validate a simulation approach for predicting pulse sequence performance in metabolite quantification.

Main Methods:

  • Simulated 11 pulse sequences (PRESS, STEAM, CPRESS, JPRESS) and acquisition parameters for accuracy and repeatability.
  • Implemented three promising sequences on a clinical scanner to compare in vivo repeatability with simulations.

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Published on: March 11, 2020

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Last Updated: Jun 19, 2026

Using Enzyme-based Biosensors to Measure Tonic and Phasic Glutamate in Alzheimer's Mouse Models
10:46

Using Enzyme-based Biosensors to Measure Tonic and Phasic Glutamate in Alzheimer's Mouse Models

Published on: May 3, 2017

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
08:27

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

Main Results:

  • Simulations showed good agreement with in vivo repeatability measures.
  • CPRESS with minimal echo time yielded the most repeatable Glu measurements within sessions, with slight overestimation.
  • JPRESS sequences demonstrated excellent accuracy but lower repeatability compared to CPRESS or PRESS.

Conclusions:

  • Simulation is a valid approach for optimizing pulse sequences for metabolite quantification.
  • CPRESS sequences offer improved within-session repeatability for in vivo Glu measurements at 3T.