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Related Experiment Video

Updated: Jun 19, 2026

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
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Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography.

G J Tearney, S A Boppart, B E Bouma

    Optics Letters
    |October 30, 2009
    PubMed
    Summary

    A new optical coherence tomography (OCT) catheter-endoscope enables micrometer-scale imaging inside organs. This 1.1 mm device uses novel fiber optics and scanning for detailed cross-sectional views of internal structures.

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    Last Updated: Jun 19, 2026

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    Published on: October 2, 2021

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    In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

    Published on: July 24, 2020

    Area of Science:

    • Biomedical Engineering
    • Medical Imaging
    • Optical Science

    Background:

    • Minimally invasive imaging of internal organs requires high-resolution, small-profile devices.
    • Existing endoscopic technologies have limitations in achieving micrometer-scale cross-sectional visualization.

    Purpose of the Study:

    • To develop and demonstrate a novel optical coherence tomography (OCT) catheter-endoscope.
    • To achieve micrometer-scale, cross-sectional imaging capabilities within internal organ systems.

    Main Methods:

    • Utilized single-mode fiber optics with a novel transverse scanning mechanism.
    • Incorporated a gradient-index lens and microprism at the distal end for beam control.
    • Achieved circumferential scanning to image transverse cross-sections.

    Main Results:

    • Developed a catheter-endoscope with a diameter as small as 1.1 mm.
    • Demonstrated micrometer-scale cross-sectional imaging capabilities.
    • Successfully imaged in vitro human venous morphology.

    Conclusions:

    • The novel OCT catheter-endoscope offers a promising tool for high-resolution internal imaging.
    • The device's small size and imaging capabilities are suitable for various internal organ applications.
    • Further research can explore in vivo applications and advanced imaging modalities.