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Updated: Jun 19, 2026

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
Published on: May 6, 2018
THE PRODUCTION OF EXPERIMENTAL NEPHRITIS BY REPEATED PROTEID INTOXICATION.
1Medical Clinic of Columbia University, College of Physicians and Surgeons, New York.
Repeated injections of foreign proteins like horse serum cause inflammatory reactions and cell injury in multiple organs. Sensitization significantly enhances kidney damage, particularly nephritis in dogs and rabbits.
Area of Science:
- Immunology
- Pathology
- Toxicology
Background:
- Repeated exposure to foreign proteins can induce immune-mediated tissue damage.
- Sensitization plays a crucial role in the severity of inflammatory responses.
Purpose of the Study:
- To investigate the cellular and tissue injuries caused by repeated injections of sensitized proteins.
- To characterize the specific organ damage, focusing on nephritis.
Main Methods:
- Injection of horse serum and egg-white into sensitized dogs, cats, rabbits, and guinea pigs.
- Histopathological examination of various organs, including liver, myocardium, and kidneys.
Main Results:
- Significant inflammatory reactions and cell injury observed in multiple organs.
- Marked nephritis characterized by tubular degeneration and necrosis in dogs and rabbits.
- Acute and chronic glomerular alterations noted across all animal groups.
Conclusions:
- Repeated administration of sensitized proteins leads to widespread organ damage.
- Kidney injury, including nephritis, is a prominent outcome, exacerbated by prior sensitization.
- The study highlights the pathological consequences of immune-mediated reactions to foreign proteins.
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