THE RELATIONSHIP OF CHRONIC PROTEIN INTOXICATION IN ANIMALS TO ANAPHYLAXIS.

Area of Science:

• Immunology
• Pathology
• Toxicology

Background:

• Foreign proteins, such as horse serum and egg-white, are commonly used in experimental settings.
• The immediate effects and delayed pathological changes following foreign protein injection require further elucidation.

Purpose of the Study:

• To investigate the immediate and delayed effects of foreign protein injections in rabbits.
• To understand the relationship between antibody formation and the development of organ lesions.

Main Methods:

• Rabbits were injected with foreign proteins (horse serum, egg-white).
• Animals were monitored for signs of intoxication and organ damage.
• Antibody levels were assessed in relation to observed pathological changes.

Main Results:

• No immediate intoxication was observed after foreign protein injection.
• Single large injections led to parenchymatous organ changes (myocardium, liver, kidneys) 10-21 days post-injection.
• Lesion development correlated with the formation of antibodies against the foreign proteins.

Conclusions:

• The mechanism of organ damage by foreign proteins is linked to the host's immune response (antibody formation).
• While single injections cause damage, repeated inoculations in sensitized animals result in more severe and widespread lesions.