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[Radial access and management of patients with long-term oral anticoagulation for cardiac catheterization]
1Laboratoire d'hémodynamique et de cardiologie interventionnelle, service de physiologie et des explorations fonctionnelles, hôpital Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil cedex, France. pierre-francois.lesault@hmn.aphp.fr
Insights
Patients on long-term oral anticoagulation undergoing angioplasty face high bleeding risks. This review explores managing antithrombotic therapy post-stenting to balance ischemic and bleeding events for better outcomes.
Area of Science:
- Cardiology
- Interventional Cardiology
- Pharmacology
Context:
- Patients on long-term oral anticoagulation (OAC) have increased bleeding risk, especially during invasive procedures like angioplasty.
- Angioplasty and stenting in OAC patients necessitate careful management of antithrombotic therapy to mitigate bleeding and ischemic complications.
- Current guidelines lack specific recommendations for post-stenting antithrombotic regimens in OAC patients, posing a clinical challenge.
Purpose:
- To review current data on angioplasty and antithrombotic therapy in patients on long-term oral anticoagulation.
- To propose a treatment paradigm to optimize long-term prognosis for these high-risk patients.
Summary:
- Long-term oral anticoagulation increases bleeding risk during angioplasty, often leading to temporary therapy interruption.
- Balancing ischemic and bleeding risks post-stenting is challenging due to a lack of specific recommendations.
- Uninterrupted OAC, transradial approach, and risk stratification can minimize long-term complications.
Impact:
- Provides a comprehensive review of angioplasty management in OAC patients.
- Proposes a treatment strategy to improve long-term outcomes and reduce complications.
- Aims to guide clinicians in managing antithrombotic therapy for stented patients on long-term OAC.
Abstract:
Patients with long-term oral anticoagulation are exposed to high bleeding risk and should be managed with care for invasive procedure. Angioplasty is assumed to increase bleeding and access site complications and it is often recommended to temporarily interrupt anticoagulation therapy. Moreover, due to the lack of recommendations, antithrombotic regimen adopted after stenting represents a substantial challenge for the physician who must balance the risk of ischemic and bleeding events. Nevertheless, approaches as uninterrupted therapeutic oral anticoagulation, transradial approach and a best knowledge of ischemic risk, haemorrhage risk and restenosis risk can limit long term complication. Herein, we review the currently available data assessing angioplasty and long-term antithrombotic therapy for stented patients with long-term oral anticoagulation and we propose a potential treatment paradigm to improve long-term prognosis.
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