[Involvement of mucous membranes in papulosquamous diseases]

M Sticherling1

  • 1Hautklinik, Universitätsklinikum Erlangen, 91052 Erlangen. michael.sticherling@uk-erlangen.de

Insights

Skin diseases can affect oral and genital mucous membranes, though it is uncommon. Lichen planus is the most frequent cause, requiring dermatologic care for potential complications like neoplasia.

Area of Science:

  • Dermatology
  • Oral Medicine
  • Pathology

Context:

  • Mucous membrane involvement by skin diseases is generally uncommon.
  • Lichen planus, psoriasis, and lupus erythematosus are key dermatoses affecting these sensitive tissues.
  • Macroscopic changes range from erythema and erosions to leukoplakia.

Purpose:

  • To review the presentation and management of skin diseases affecting oral and genital mucous membranes.
  • To differentiate mucosal symptoms from psychiatric disorders and identify potential complications such as neoplasia.
  • To emphasize the need for appropriate dermatologic care.

Summary:

  • Skin conditions infrequently manifest on oral and genital mucous membranes.
  • Lichen planus is the most common dermatosis, presenting with varied lesions.
  • Burning sensations and pain require careful evaluation to exclude neoplasia and psychiatric conditions.

Impact:

  • Highlights the importance of recognizing and managing uncommon dermatologic presentations in mucous membranes.
  • Underscores the necessity of distinguishing symptoms to guide appropriate therapy, including local and systemic treatments.
  • Stresses the requirement for ongoing dermatologic surveillance to manage potential complications and ensure optimal patient outcomes.

Related Concept Videos

Surface Membrane Barriers01:18

Surface Membrane Barriers

The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents01:24

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors01:24

Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors

Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI)  tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining. Bicarbonate,...
Tissue Membranes01:27

Tissue Membranes

A tissue membrane is a thin layer of cells that covers the outside of the body, the organs, internal passageways that lead to the exterior of the body, and the lining of the moveable joint cavities. There are two basic types of tissue membranes— connective tissue and epithelial membranes.
Connective Tissue Membranes
The connective tissue membrane is formed solely from connective tissue. These membranes encapsulate organs, such as the kidneys, and line our movable joints. A synovial membrane is...
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...