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From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Multiple convergence in polyketide biosynthesis: a third folding mode to the anthraquinone chrysophanol
Gerhard Bringmann1, Tobias A M Gulder, Andreas Hamm
1Institute of Organic Chemistry, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany. bringman@chemie.uni-wuerzburg.de
Abstract:
The polyketide chrysophanol is shown to be formed, in an organism-specific way, by a third folding mode, involving a remarkable cyclization of a bicyclic diketo precursor, thus establishing the first example of multiple convergence in polyketide biosynthesis.
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