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Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response

Matthijs L Becker1, Loes E Visser, Ron H N van Schaik

  • 1Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.

Pharmacogenetics and Genomics
|November 10, 2009
PubMed
Summary

Genetic variations in organic cation transporter 1 (OCT1) and multidrug and toxin extrusion 1 (MATE1) influence metformin's glucose-lowering effects. An interaction between OCT1 rs622342 and MATE1 rs2289669 polymorphisms significantly impacts metformin efficacy.

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