Related Experiment Video
Updated: Jun 18, 2026
10:10
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
Published on: February 15, 2022
[Steroid induced ocular hypertension and glaucoma].
Oftalmologia (Bucharest, Romania : 1990)
|November 11, 2009
Summary
Steroid-induced ocular hypertension and glaucoma are iatrogenic conditions caused by exogenous steroids. While high ocular pressure often resolves after stopping steroids, optic nerve damage can still occur.
Area of Science:
- Ophthalmology
- Pharmacology
- Glaucoma Research
Context:
- Steroid-induced ocular hypertension and glaucoma are iatrogenic conditions resulting from exogenous steroid use.
- Administration routes include ocular, periocular, intravitreal, and systemic.
- These conditions involve structural changes and outflow obstruction within the trabecular juxtacanalicular area.
Purpose:
- To describe the mechanisms and consequences of steroid-induced ocular hypertension and glaucoma.
- To highlight the potential for progressive optic nerve damage despite steroid cessation.
- To outline therapeutic approaches for these conditions.
Summary:
- Exogenous steroids can cause iatrogenic ocular hypertension and glaucoma via trabecular meshwork changes and aqueous humor outflow obstruction.
- Elevated intraocular pressure typically normalizes post-steroid withdrawal, but irreversible optic nerve damage and visual field defects may persist.
- Treatment strategies mirror those for ocular hypertension and primary open-angle glaucoma.
Impact:
- Understanding the pathophysiology of steroid-induced glaucoma is crucial for timely diagnosis and management.
- This knowledge aids in preventing irreversible vision loss associated with steroid therapy.
- Informs clinical practice regarding monitoring and treatment of patients exposed to corticosteroids.
Related Concept Videos
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
01:23Ophthalmic Drug Delivery Systems
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...