Simultaneous LC/MS analysis of hexachlorobenzene and pentachlorophenol by atmospheric pressure chemical ionization (APCI) and photoionization (APPI) methods
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Updated: Jun 18, 2026

Characterization and Application of Passive Samplers for Monitoring of Pesticides in Water
Published on: August 3, 2016
Issey Osaka1, Arifumi Yoshimoto, Kazuyoshi Nozaki
1Center for Nano Materials and Technology, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa 923-1294, Japan.
Abstract:
The simultaneous LC/MS analyses of hexachlorobenzene (HCB) and pentachlorophenol (PCP), two dioxin precursors were studied by both atmospheric pressure chemical ionization (APCI) and atmospheric pressure photoionization mass spectrometry (APPI/MS). The optimum LC/MS conditions of the simultaneous analysis were determined for these two compounds with different polarity. Ionization by APPI was found to be more effective than by APCI, and is thus a better ionization method for analysis of the two compounds. Using LC/APPI/MS we can achieve the simultaneous analysis of HCB and PCP at ppb levels.
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